There aren't a ton of negatives...serious. The remote work is challenging at times but if you are organized, diligent, and a great multi-tasker, it'll be easier. Working with every single time zone is probably the most challenging in terms of cons...but there's solutions to address this. The fast paced nature of the "business" does get hairy to navigate and work load can be daunting at times...but for me, the pros outweigh the cons by far.