Lowe's does not accept unsolicited resumes or applications. They post a position online and leave it up until a few weeks have passed or until they get too many applications. Some positions are up only for a few days.
After putting in my online application, I was called in for an interview with the HR manager. It was very pleasant, she was very nice and even let me change answers a few times. Some of the questions like "Tell about a time management was not around and you had to make an executive decision", I had a hard time with. But if I ever gave a lame answer she would usually go over the answer with me, ask questions of her own, then write down that finalized answer. I thought that was super nice, because sometimes you don't have a great answer right away, so she basically made sure each of my answers were dynamite. This first interview took about 30 minutes.
After that interview, a week or so went by and I was called back for an interview with an assistant store manager. This one was a little tougher, I could tell he would not help me with my statements so I had to be much more careful. This interview was much quicker, I think he only asked 5 questions or so that required some explanation on my part. The questions were along the line of "what would you do if...?", so my answers were not as concrete as questions about my past (from the first interview). Overall not bad though, I think this interview is a chance for that manager to see you for himself, since you'll be working with them daily.