The best way to answer "Tell me about yourself" is with a brief highlight-summary of your experience, your education, the value you bring to an employer, and the reason you're looking forward to learning more about this next job and the opportunity to work with them.
Use numbers to quantify how many years of experience you have, or the percentage of growth you created for your previous employer. Know that this is not the time to give them a lengthy laundry list of all that you've done, but to focus on your best qualifications for this job.
When you answer "Tell me about yourself," that's your opportunity to draw them in and intrigue them to want to find out more about you throughout the rest of the interview. Last, always know that your answer to this question is never about your personal life; it's always about who you are as a professional.